论文标题:PL偶联剂改性羟基磷灰石/高密度聚乙烯复合人工骨材料的制备和性能研究
Studies on Preparation and Properties of Modified Hydroxyapatite/High Density Polyethylene Artificial Bone Composites
论文作者 罗庆平
论文导师 尹光福,论文学位 硕士,论文专业 生物医学工程
论文单位 四川大学,点击次数 18,论文页数 73页File Size2699k
2003-05-20论文免费下载 http://paper.dic123.com/lunwen_275984077/ 磷酸单醋(PL)偶联剂,表面改性,制备和性能,羟基磷灰石/高密度聚乙烯复合材料,溶解率,血液相容性
monophosphatase (PL) coupling agent,surface modification,preparation and properties,HA/HDPE composite,the rate of dissolution,blood compatibility
本论文研究了中和沉淀法制备羟基磷灰石(HA)的工艺；用磷酸单酯(PL)偶联剂通过熔化、共混复合工艺对HA进行了表面改性，制备出经过PL偶联剂改性的HA／高密度聚乙烯(HDPE)复合人工骨生物材料；并对复合材料的结构与理化性能、生物学性能进行了基础研究。 对PL偶联剂对HA表面改性的工艺条件进行了研究。通过研究HA的粒度、HA的煅烧温度、偶联剂加量以及共混复合条件对HA表面改性性能的影响，得到以下结论：磷酸单酯(PL)是一种高效的表面改性偶联剂，具有较高的反应活性，能与HA表面的羟基(-OH)发生化学反应而形成稳固的键合。其较佳的表面改性工艺条件：HA煅烧温度：1000℃；偶联剂加量：0.7wt％。 对改性HA／高密度聚乙烯复合材料的制备和性能进行了研究。结果表明，该改性复合材料具有较好的流变学性能和加工性能；较好的均一性和热稳定性。PL偶联剂改善了HA与HDPE两相界面间的结合性能，提高了HA在高密度聚乙烯基体中的分散度和填充量。随着复合材料中HA含量的增加，材料的弯曲强度、弯曲模量有大幅提高，而材料的抗拉强度即韧性降低不大。通过PL偶联剂在复合材料中的“桥联”作用，达到了在复合材料中HA弥散增强材料抗压强度、HDPE对HA进行增韧的目的。通过控制复合材料中HA与HDPE的配比，可制备出机械力学性能优良的人工骨复合生物材料。 PL偶联剂改性经基磷灰石/高密度聚乙烯复合人工骨材料的制备和性能研究 通过对改性IJ户口高密度聚乙烯复合材料在模拟体液(S BF)中的溶解试验，以及血液相容性试验，研究了该复合材料的生物学特性。结果表明，该复合材料是一种非降解性生物材料，就动态凝血时间和溶血率两个血液相容性指标来看，该复合材料具有比聚乙烯更好的血液相容性。
The hydroxyapatite (HA) was prepared by the method of neutralization deposit, and its surface modification was carried out using monophosphatase (PL) coupling agent through fusing and mixing. The modified HA / high density polyethylene (HDPE) artificial bone composites were prepared. The structure and physical, chemical and biological properties of the composites have been studied in the present master thesis.The influences of the diameter of HA, the calcining temperature of HA, the addition of coupling agent and mixing conditions on surface modification of HA have been studied. The results showed that the monophosphatase (PL) was a kind of excellent surface modification coupling agent with good reactivity, it could react with the hydroxyl (-OH) in HA surface and form a stable chemical bond. The optimum process conditions in surface modification were obtained: the HA calcining temperature:1000℃, the addition of PL coupling agent: 0.7wt%.The preparation and properties of modifiied HA / HDPE composites have been investigated also in this study. The results showed that the modified composites possessed good rheological properties, machinability, homogeneity and thermal stability. PL coupling agent could enhance the interface combination between HA and HDPE, and improve the dispersibility and fill content of HA in the HDPE basis.With the increase in HA content, the flexural strength and flexure modulus of composites had been greatly increased and the tensile strength of composites had only a little change. Through the "bridge -connection" action of PL coupling agent, it could be realized to increase the strength of composites by the dispersion of HA, and to improve the tougheness of composites through the tenacity addition action of HDPE. The artificial bone composites with good mechanical properties might be prepared through controlling the content of HA or HDPE in the composites.The biological properties of HA/HDPE composites were studied through the vitro dissolution test of composites in the simulated body fluid (SBF) and the blood compatibility test of composites. The results showed that the composites were a kind of non-degradable biomaterials. The evaluations with kinetic clotting times and hemolysis showed that the composites possessed better blood compatibility than polyethylene.
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